1. Sjef Verbeek, Ph.D., Associate Professor, group leader
Department of Human Genetics, S-4-P
Leiden University Medical Center
Albinusdreef 2
2333 ZA Leiden
The Netherlands
Fax: +31-71-5268285
Email address: j.s.verbeek@lumc.nl
http://www.lumc.nl/rep/cod/redirect/3098/research/immunogenetics/index.html
Sjef Verbeek, Ph.D, has extensive
experience in the generation and phenotypic analysis of genetically modified mice in a wide range of
medical areas, cancer, diabetes, neurological disorders and immunology. In immunology he gained an unique
position by generating a complete set of all combinations of FcgR deficient mice. In collaboration with
outstanding laboratories in the field in Japan, the US and Europe the role of FcgR in the effector
pathways of IgG have been studies in disease models of arthritis, nephritis, vasculitis, EAE, hemolytic
anemia, prion disease and in bacterial infections. In these mouse models the specific contribution of
the different FcgR and complement in downstream effector pathways of the immune response could be defined.
Moreover, a modulating role of FcgR in the immune response was identified. FcgR can effectively facilitate
antigen presentation by professional antigen presenting cells.
Appointed research fellows
Experienced researcher: Victoria Arandhara, United Kingdom
Appointed on the IMDEMI project from 1-11-2005 to 30-04-2008
Experienced researcher: Jordana Todorova,
Bulgaria
Appointed on the IMDEMI project 1-2-2009 to 31-5-2009
Early stage researcher: Javier Martin Ramirez, Spain
Appointed on the IMDEMI project 1-8-2006 to 31-5-2009
Early stage researcher: Ahmad Sattardeh, Iran
Appointed on the IMDEMI project 1-11-2008 to 31-5-2009
Early stage researcher: Gloria Comadira Miguel, Spain
Appointed on the IMDEMI project 1-2-2009 to 31-5-2009
Early stage researcher: Elisenda Alsina Sanchis, Spain
Appointed on the IMDEMI project 1-3-2009 to 31-5-2009
Early stage researcher: Dominika Lukas, Poland
Appointed on the IMDEMI project 1-3-2009 to 31-5-2009
Early stage researcher: Peter Kalev, Bulgaria
Appointed on the IMDEMI project 1-3-2009 to 31-5-2009
Publications
originating from the
IMDEMI project
Boross P, van Lent PL, Martin-Ramirez
J, van der Kaa J, Mulder MH, Claassens JW, van den Berg WB, Arandhara VL,
Verbeek JS. Destructive arthritis in the absence of both FcgammaRI and
FcgammaRIII. J Immunol 180: 5083-5091, 2008.
(PDF)
Woelbing F, Kostka SL, Moelle K, Belkaid Y, Sunderkoetter C, Verbeek S,
Waisman A, Nigg AP, Knop J, Udey MC, von Stebut E. Uptake of Leishmania
major by dendritic cells is mediated by Fcgamma receptors and facilitates
acquisition of protective immunity.
J Exp Med 203: 177- 188, 2006.
(PDF)
Publications
Sjef Verbeek
(link to PubMed)
_______________________________________________________________________________________________
Mohamed R Daha, professor, group leader
Dept. of Nephrology, C3-P
Leiden University Medical Center
Albinusdreef 2
2333 ZA Leiden
The Netherlands
Fax: +31-71-5266868
Email address: m.r.daha@lumc.nl
Mohamed R. Daha, Ph.D, has extensive research experience in immunology of renal disease,
autoimmunity and basic research in the areas of humoral and cellular immunology in relation to
inflammation and chronic transplant rejection. His group has contributed to major developments in
the field of complement and autoimmune renal diseases. Next to clinical/nephrological research his
focus is also in renal disease in experimental models of animal disease. These studies serve to analyse
the mechanisms underlying the development and course of glomerular and interstitial inflammation in the
kidney. The active contribution of renal epithelial in the immune and inflammatory response has been
demonstrated.
Publications
Mohammed Daha
(link to PubMed)
|
